The evolution of koala retroviruses: insights from other endogenous retroviruses
نویسندگان
چکیده
منابع مشابه
Endogenous Retroviruses and Human Evolution
Humans share about 99% of their genomic DNA with chimpanzees and bonobos; thus, the differences between these species are unlikely to be in gene content but could be caused by inherited changes in regulatory systems. Endogenous retroviruses (ERVs) comprise approximately 5% of the human genome. The LTRs of ERVs contain many regulatory sequences, such as promoters, enhancers, polyadenylation sign...
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Endogenous retroviruses (ERVs) appear to have a particular predilection for placentas: retroviral genes have repeatedly been coopted for placental functions. In this issue, Chuong draws attention to the important contribution of retroviral promoters in rewiring placental development [1]. He proposes that trophoblast cells provide a permissive epigenetic environment for ERV activity because plac...
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Endogenous retroviruses are normal constituents in vertebrate genomes. They have been associated with various diseases of presumed autoimmune etiology. However, conclusive evidence of their significance as susceptibility factors in these diseases is still lacking. In our laboratory we have focused attention upon endogenous retroviruses as candidate genes in multiple sclerosis. In this communica...
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Murine leukemia viruses (MuLVs) are the prototypical gammaretroviruses, and they have been extensively studied with regard to how they cause disease. Leukemogenesis by two MuLVs is reviewed here: the endogenous Akv MuLV of AKR mice, and exogenous Moloney MuLV. Important features of MuLV leukemogenesis include the in vivo generation of envelope recombinants (MCFs) through recombination with endo...
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ژورنال
عنوان ژورنال: Technical Reports of the Australian Museum, Online
سال: 2014
ISSN: 1835-4211
DOI: 10.3853/j.1835-4211.24.2014.1606